2 Such individuals apparently have a problem with iron transport into the CSF. Even people with the genetic disease hemochromatosis (iron overload and hence high serum ferritin) can have low CSF ferritin-and RLS. CSF ferritin may or may not be correlated with serum ferritin. 1 Iron is a necessary cofactor for tyrosine hydroxylase, an enzyme involved in the formation of dopamine, a neurotransmitter involved in controlling movement. Restless leg syndrome (RLS), characterized by an uncontrollable urge to move one’s legs, especially at night and worsening with rest, is highly correlated with low ferritin in the cerebral spinal fluid (CSF). Iron supplementation can raise iron stores. Tiredness is a symptom of low iron stores, but tiredness can have many other causes. Without the blood test, you may not know whether your iron stores are deficient. A blood test for ferritin, an iron storage molecule in the blood, can detect low iron stores even when anemia is not present. Low iron stores precede anemia and may be associated with tiredness, since iron is involved in energy production. Iron deficiency can result from too little iron in the diet, blood loss, or excessive blood cell destruction (caused by some drugs and certain disease conditions). Anemia can be caused by many things, and iron supplementation is appropriate only when the cause of the anemia is iron deficiency. Symptoms of anemia include fatigue, pale skin, weakness, and possibly dizziness. Anemia is a state of having too few red blood cells and/or too little hemoglobin, the molecule that carries oxygen, in the red blood cells.
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